Gotten some version of "the speech," which consists of a warning about TRT possibly causing prostate cancer and the need for frequent, humiliating exams possibly made all the worse because of a freakishly long index finger with knuckles the size of hambones.
That ominous speech is but one repercussion of the work of Charles Brenton Huggins and Clarence Hodges, two researchers from the 1940s who noticed that patients with metastatic prostate cancer lived a bit longer than expected when they were castrated.
This led them – and several generations of doctors that succeeded them – to assume it was testosterone itself that promoted prostate cancer.
  I should be a little more specific, though. Huggins and Hodges assumption was based on ONE guy with metastatic cancer who lived longer than he was supposed to because he was castrated. (1) Talk about a paucity of data! Talk about a small sampling size!
Hell, my Uncle Uno died from a heart attack a few hours after eating a bowl of Fruit Loops. You don't see me warning the whole world that Fruit Loops cause heart attacks.

Anyhow, far fewer docs are now furrowing their brows over the alleged connection between TRT and prostate cancer. The studies just don't back it up.
Furthermore, a new study – one that was based on information from a large U.S. commercial insurance research database – found that not only does TRT not correlate with new cases of prostate cancer, it appears it might actually prevent them.
[Image: Cancer-1.jpg]WHAT THE DATABASE INDICATEDThe researchers looked at 189,491 men between the ages of 40 and 60 in the IBM MarketScan Commercial Database. (2) Men who had received the greatest number of testosterone injections (more than 12) were 33% less likely to have developed prostate cancer than men who had received the fewest number of injections (1-2).
They also found a similar inverse association between men who had used a testosterone topical gel. Those that used a gel for the longest time (over 330 days) had fewer cases of prostate cancer than those who had used one for a short time (between 1 and 60 days).
WHAT THIS MEANS TO YOUClearly, this study suggests that testosterone replacement therapy, at least in the short-term, and at clinically accepted levels (no more than 100 to 200 mg. a week), doesn't increase the risk of prostate cancer. In fact, based on the numbers presented, it looks like it actually wards off prostate cancer.
 However, as much as I'd like to wholly embrace these findings and sleep better at night, I realize that they may be influenced by possible confounding factors, which is statistics-ese for factors that may mask an actual association, or falsely demonstrate an apparent association where none exists.

Still, these number look pretty damn comforting, especially when matched up with a number of other reports, including another insurance database study that had similar findings. (3) The jury may still be out on whether sane doses of testosterone can cause prostate cancer, but 10 or 11 of the 12 angry men look like they're ready to acquit.
I think the issue is that exogenous testosterone can raise your PSA level, which is usually used as an indicator for an enlarged prostate and the inflammation is being caused by cancer. And while I agree that there does appear to be a correlation between increased T level and increased PSA, I'm not convinced the increased PSA is a result of prostate inflammation.

My PSA is currently coming down, but I've been making an effort to get my T level back into cruise mode (600-800), however, even when my PSA was elevated, I had no symptoms of an enlarged prostate (flow issues, nocturia, etc) and my recollection is the "digital exam" was not conclusive (my prostate "rides high" and is hence harder to reach).

Anyway, I may do some more research into this next time I'm blasting (soon) and see what current research is saying. I'm currently still finishing up my research into hemotology and neurology, so my plate is pretty full right now.
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[-] The following 1 user gave Gainz for MuscleMonkey's post:
  • scoobs88
Damn right this best news I heard in awhile!!!

Quote:Only 3 studies provided data with respect to the development of prostate cancer, and rates were similar between those that received treatment and controls.Testosterone replacement therapy does not increase PSA levels in men being treated for hypogonadism, except when it is given IM and even the increase with IM administration is minimal.

So, there you have it. This corresponds with my observation that my PSA does go up when I'm blasting, but when I'm cruising it's on the high end of normal.
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